The End of the RNA World Is Near, Biochemists Argue

– The RNA world doesn’t tell you anything about genetics…

Peter Wills

The RNA-Peptide World
Life might have originated from interactions between RNA and peptides that acted as the first genetic code. A self-sustaining loop of reactions would have built enzymes by choosing between only two types of amino acids instead of the 20 in today’s proteins.
1. “Loading enzymes” match against the sequence of bases in RNA and help create peptide chains of linked Class I and Class II amino acids.
2. The peptide chains fold into functional shapes.
3. Depending on their shape, the chains pick up either Class I or Class II amino acids and become active loading enzymes.
4. The enzymes interact with the RNA and deliver their amino acid payload to the forming chains.


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